I-15 and I-80 are the main interstate highways in the state, where they intersect and briefly merge near downtown Salt Lake City. I-15 traverses the entire state north-to-south, entering from Arizona near St. George, traversing the entire Wasatch Front, and exiting into Idaho near Portage. I-80 spans northern Utah east-to-west, entering from Nevada at Wendover, crossing the Wasatch Mountains east of Salt Lake City, and entering Wyoming near Evanston. I-84 West enters from Idaho near Snowville (from Boise) and merges with I-15 from Tremonton to Ogden, then heads southeast through the Wasatch Mountains before terminating at I-80 near Echo Junction.

I-70 splits from I-15 at Cove Fort in central Utah and heads east through mountains and rugged desert terrain, providing quick access to the many national parks and national monuments of southern Utah, and has been noted for its beauty. The 103 mile (163 km) stretch from Salina to Green River is the longest stretch of interstate in the country without services, and, when completed in 1970, was also the longest stretch of entirely new highway constructed in the U.S. since the Alaska Highway was completed in 1943.

A light rail system in the Salt Lake Valley, known as TRAX, consists of two lines, both ending in Downtown Salt Lake City, with one heading to the suburb of Sandy and the other to the University of Utah. The system is currently undergoing an expansion that will see the completion of four additional lines by 2014. The Utah Transit Authority (UTA), which operates TRAX, also operates a bus system that stretches across the Wasatch Front and west into Tooele, and also provides winter service to the ski resorts east of Salt Lake City. Several bus companies provide access to the ski resorts in winter, and local bus companies also serve Logan, St. George and Cedar City. A commuter rail line known as FrontRunner currently operates between Salt Lake City and Pleasant View, and is also currently undergoing an expansion south to Provo. Amtrak's California Zephyr, with one train in each direction daily, runs east-west through Utah with stops in Green River, Helper, Provo, and Salt Lake City.

Salt Lake City International Airport is the only international airport in the state and serves as a hub of Delta Air Lines. The airport has consistently ranked first in on-time departures and had the fewest cancellations among U.S. airports. The airport currently has non-stop service to over 100 destinations throughout the United States, Canada, and Mexico, as well as to Paris and Tokyo. Canyonlands Field (near Moab), Cedar City Regional Airport, St. George Municipal Airport, and Vernal-Uintah County Airport all provide limited commercial air service. Ground has recently been broken on creating a new, larger regional airport in St. George, due to the rapidly-growing population and the lack of room for expansion for the current airport. Completion is expected in 2011. SkyWest Airlines is also headquartered in St. George and maintains a hub at Salt Lake City.